Endocrine Abstracts

C-type natriuretic peptide (CNP) has recently been implicated as a key meiotic arrest factor in oocytes, and mechanistic studies suggest that the transcriptional regulation of the CNP gene (Nppc) and of its receptor, GC-B (Npr2) is sensitive to gonadotrophin-dependent cAMP accumulation. We have shown CNP to be a major regulator of gonadotrophs in the pituitary, but have yet to establish how either Nppc or Npr2 are transcriptionally controlled locally. In the current study, the...